Studies on Southeast Asian Ovalocytosis (SAO) and Diegoa blood group antigen in the Malay Population.
2. Studies on Southeast Asian Ovalocytosis (SAO) and Diegoa blood group antigen in the Malay Population.
Author :: Yamunah R, Sanmukh R J, Narazah M Y Date :: Mon 12/30/2013 @ 10:58
Background and objective: The South East Asian ovalocytosis (SAO) is a red blood cell (RBC) abnormality, common in South East Asian (SEA) countries including Malaysia, due to a defective anion exchanger protein Band 3 (AE1, SLC4A1). Diego blood groups antigens, associated with SEA population are also present on Band 3 protein. There is no report showing association, if any, between these two traits. The present study is an attempt to address this issue. Study design: This study was carried out through two experimental strategies. At first, 71 normal healthy individuals screened for both the SAO and the Diego blood groups. The second strategy involved testing red cells for Dia antigen among 39 Malaysian patients known to have SAO. Examination of peripheral blood smear (PBS) for SAO and the indirect antiglobulin test to be performed on commercial reagent for the Diego blood group typing the red cells were the methodology involved in the study. Results: Among the 71 healthy Malay subjects tested, one individual was found to possess Dia antigen and 3 persons showed SAO, giving a frequency of 1.43% and 4.41% respectively. The donor with Dia antigen did not show a presence of SAO in PBS nor any of the 3 healthy individuals and 39 patients with SAO showed a presence of Dia. Conclusion: The study did not reveal any association between the Diego blood groups and SAO among the limited number of blood samples from Malaysian individuals tested.
Keywords: Ovalocytosis, Dia antigen, Malay population
2. Studies on Southeast Asian Ovalocytosis (SAO) and Diegoa blood group antigen in the Malay Population. Author :: Yamunah R, Sanmukh R J, Narazah M Y Date :: Mon 12/30/2013 @ 10:58
Background and objective: The South East Asian ovalocytosis (SAO) is a red blood cell (RBC) abnormality, common in South East Asian (SEA) countries including Malaysia, due to a defective anion exchanger protein Band 3 (AE1, SLC4A1). Diego blood groups antigens, associated with SEA population are also present on Band 3 protein. There is no report showing association, if any, between these two traits. The present study is an attempt to address this issue. Study design: This study was carried out through two experimental strategies. At first, 71 normal healthy individuals screened for both the SAO and the Diego blood groups. The second strategy involved testing red cells for Dia antigen among 39 Malaysian patients known to have SAO. Examination of peripheral blood smear (PBS) for SAO and the indirect antiglobulin test to be performed on commercial reagent for the Diego blood group typing the red cells were the methodology involved in the study. Results: Among the 71 healthy Malay subjects tested, one individual was found to possess Dia antigen and 3 persons showed SAO, giving a frequency of 1.43% and 4.41% respectively. The donor with Dia antigen did not show a presence of SAO in PBS nor any of the 3 healthy individuals and 39 patients with SAO showed a presence of Dia. Conclusion: The study did not reveal any association between the Diego blood groups and SAO among the limited number of blood samples from Malaysian individuals tested.
Keywords: Ovalocytosis, Dia antigen, Malay population
2. Studies on Southeast Asian Ovalocytosis (SAO) and Diegoa blood group antigen in the Malay Population. Author :: Yamunah R, Sanmukh R J, Narazah M Y Date :: Mon 12/30/2013 @ 10:58
Background and objective: The South East Asian ovalocytosis (SAO) is a red blood cell (RBC) abnormality, common in South East Asian (SEA) countries including Malaysia, due to a defective anion exchanger protein Band 3 (AE1, SLC4A1). Diego blood groups antigens, associated with SEA population are also present on Band 3 protein. There is no report showing association, if any, between these two traits. The present study is an attempt to address this issue. Study design: This study was carried out through two experimental strategies. At first, 71 normal healthy individuals screened for both the SAO and the Diego blood groups. The second strategy involved testing red cells for Dia antigen among 39 Malaysian patients known to have SAO. Examination of peripheral blood smear (PBS) for SAO and the indirect antiglobulin test to be performed on commercial reagent for the Diego blood group typing the red cells were the methodology involved in the study. Results: Among the 71 healthy Malay subjects tested, one individual was found to possess Dia antigen and 3 persons showed SAO, giving a frequency of 1.43% and 4.41% respectively. The donor with Dia antigen did not show a presence of SAO in PBS nor any of the 3 healthy individuals and 39 patients with SAO showed a presence of Dia. Conclusion: The study did not reveal any association between the Diego blood groups and SAO among the limited number of blood samples from Malaysian individuals tested.
Keywords: Ovalocytosis, Dia antigen, Malay population
2. Studies on Southeast Asian Ovalocytosis (SAO) and Diegoa blood group antigen in the Malay Population. Author :: Yamunah R, Sanmukh R J, Narazah M Y Date :: Mon 12/30/2013 @ 10:58
Background and objective: The South East Asian ovalocytosis (SAO) is a red blood cell (RBC) abnormality, common in South East Asian (SEA) countries including Malaysia, due to a defective anion exchanger protein Band 3 (AE1, SLC4A1). Diego blood groups antigens, associated with SEA population are also present on Band 3 protein. There is no report showing association, if any, between these two traits. The present study is an attempt to address this issue. Study design: This study was carried out through two experimental strategies. At first, 71 normal healthy individuals screened for both the SAO and the Diego blood groups. The second strategy involved testing red cells for Dia antigen among 39 Malaysian patients known to have SAO. Examination of peripheral blood smear (PBS) for SAO and the indirect antiglobulin test to be performed on commercial reagent for the Diego blood group typing the red cells were the methodology involved in the study. Results: Among the 71 healthy Malay subjects tested, one individual was found to possess Dia antigen and 3 persons showed SAO, giving a frequency of 1.43% and 4.41% respectively. The donor with Dia antigen did not show a presence of SAO in PBS nor any of the 3 healthy individuals and 39 patients with SAO showed a presence of Dia. Conclusion: The study did not reveal any association between the Diego blood groups and SAO among the limited number of blood samples from Malaysian individuals tested.
Keywords: Ovalocytosis, Dia antigen, Malay population
