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Recent Publications

2018

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2017


The Use of mesenchymal stromal cells in treatment of lung disorders
E Kardia, N Zakaria, NSSA Halim, D Widera, BH Yahaya
Regen Med. 2017 Mar;12(2):203-216. doi: 10.2217/rme-2016-0112. Epub 2017 Feb 17

Aerosol‐based Airway Epithelial Cell Delivery Improves Airway Regeneration and Repair
E Kardia, ES Ch'ng, BH Yahaya
J Tissue Eng Regen Med. 2017 Jan 20. doi: 10.1002/term.2421.

Targeting Lung Cancer Stem Cells: Research and Clinical Impacts
Norashikin Zakaria, Nazilah Abdul SatarNoor Hanis Abu Halim, Siti Hawa Ngalim, Narazah Mohd Yusoff and Juntang Lin, Badrul Hisham Yahaya
Front. Oncol. 7:80. doi: 10.3389/fonc.2017.00080

Does inhalation of virgin coconut oil accelerates reversal of airway remodelling in an allergic model of asthma?
Nurulain 'Atikah Kamalaldin, Siti Amrah Sulaiman, Rahimi M. Yusop and Badrul Hisham Yahaya
International Journal of Inflammation. 
Volume 2017 (2017), Article ID 8741851, 11 pages

Physico-mechanical properties of HA/TCP pellets and their three-dimensional biological evaluation in vitro
Nurulain ‘Atikah Kamalaldin, Mariatti Jaafar, Saiful Irwan Zubairi, Badrul Hisham Yahaya
Advances in Experimental Medicine and Biology (In-press)

An analysis of genetic association in opiod dependence susceptibility
Devaki Nagaya, Zalina Zahari, Mohamed Saleem, Badrul Hisham Yahaya, Tan Soo Choon, Narazah Mohd Yusoff
J Clin Pharm Ther. 2017 Jun 27. doi: 10.1111/jcpt.12585.

Stimulatory Secretions of Airway Epithelial Cells Accelerate Early Repair of Tracheal Epithelium. E Kardia, R Mohamed, BH Yahaya. Scientific reports 7, 11732 

Aerosol-based cell delivery as an innovative treatment for lung diseases
BH Yahaya, NSS Abdul Halim, E Kardia
Biomedical Research and Therapy 4 (S), S41-S41

Lung cancer stem cell and its therapeutic potential
BH Yahaya, N Zakaria, NHA Halim, N Satar
Biomedical Research and Therapy 4 (S), S15-S16

Direction of commissural axon projections in different regions of the spinal cord during chicken embryonic development.
H Li, C Yang, NM Yusoff, BH Yahaya, J Lin.
Neuroscience 358, 269-276

2016

Physico-chemical and biological activity of Malaysian channa striatus water extract on human foetal lung cell (IMR-90)
Winnie Ngui Shy Yi, Syazwan Aizad Abdul Mutalib, Badrul Hisham Yahaya and Saiful Zubairi
Front. Bioeng. Biotechnol.  doi: 10.3389/conf.FBIOE.2016.02.00009

Coating and surface treatments enhance scaffold degradation
Nurulain Atikah Kamalaldin, Mohd Meer Saddiq Mohd Sabee, Fadhilah Darus, Mariatti Jaafar, Nurazreena Ahmad, Zuratul Ain Abdul Hamid and Badrul Hisham Yahaya
Front. Bioeng. Biotechnol.  doi: 10.3389/conf.FBIOE.2016.02.00013

Isolation and characterisation of CD166+/EpCAM+ and CD166+/CD44+as markers for cancer stem cells from non-small cell lung cancer of A549
Noor Hanis Abu Halim, Norashikin Zakaria and Badrul Hisham Yahaya
Front. Bioeng. Biotechnol.  doi: 10.3389/conf.FBIOE.2016.02.00007

Methods Mol Biol. 2016 Apr 10. [Epub ahead of print]
Aerosol-Based Cell Therapy for Treatment of Lung Diseases.
Kardia E, Halim NS, Yahaya BH.

Methods Mol Biol. 2016 Apr 1. [Epub ahead of print]
Isolation and Characterization of Cancer Stem Cells of the Non-Small-Cell Lung Cancer (A549) Cell Line.
Halim NH, Zakaria N, Satar NA, Yahaya BH. 

Procedia Chemistry 19 (2016) 373-380
Development and Evaluation of Surface Modified Poly (lactic acid) Microsphere via Irradiation Techniques for Drug Delivery System
Z.H.A. Ninaya, b, Z.A. Abdul Hamid, Z. Ahmad, M. Jaafar, B.H. Yahaya

Procedia Chemistry 19 (2016) 406-409
The Characteristics of the Smart Polymeras Temperature or pH-responsive Hydrogel
B Hilmi, ZAA Hamid, HM Akil, BH Yahaya

Procedia Chemistry 19 (2016) 297-303
Cell Evaluation on Alginate/Hydroxyapatite Block for Biomedical Application
N.A. Kamalaldin, B.H. Yahaya, A. Nurazreena

Journal of Polymer Materials Vol 33, No. 1, 2016, 191-200
Characterization and in vitro study of surface modified PLA microspheres treated with NaOH
MMS Mohd Sabee, NA Kamalaldin, BH Yahaya, ZA Abdul Hamid

Jurnal Teknologi: 78: 11–3 (2016) 19–25
Down-Regulation of ALDH1A1 increased expression of carcinogenesis-related genes in non-small cell lung cancer cell line of a549
Noor Hanis Abu Halim, Norashikin Zakaria, Badrul Hisham Yahaya

Jurnal Teknologi: 78: 11–3 (2016) 41–49 |
Proliferative activity of saponin-reducing carica papaya leaves extracts on human lung fibroblast cell (imr90)
Noraziani Zainal Abidin, Hazreen Omar, Anathasia Janam Empungan, Nurulain 'Atikah Kamalaldin, Badrul Hisham Yahaya, Saiful Irwan Zubairi

J. of Biomed. & Clin. Sci. December 2016 Vol 1 (1), 1-8
Regeneration and Repair of Damaged Trachea Epithelium following Brushing-induced Injury in Rabbits
Latahir AZ, Kardia E, Yahaya B

2015

Human non-small cell lung cancer expresses putative cancer stem cell markers and exhibits the transcriptomic profile of multipotent cells
Norashikin Zakaria, Narazah Mohd Yusoff, Zubaidah Zakaria, Moon Nian Lim, Puteri J Noor Baharuddin, Kamal Shaik Fakiruddin, Badrul Yahaya
BMC Cancer. 2015, 15:84
DOI: 10.1186/s12885-015-1086-3
URL: http://www.biomedcentral.com/1471-2407/15/84

Study the Electrical Conductivity of Cross-Linked Polymers Doped with LiClO4
Emad Yousif, Emaad T. B. Al-Tikrity, Mustafa Abdalla, Rahimi M. Yusop, Badrul Hisham Yahaya, Darfizzi Derawi
Int. J. Electrochem. Sci., 10 (2015) 2055 – 2063

Preparation and characterization of HypoGel‐supported Pd nanocatalysts for Suzuki reaction under mild conditions
Kin Hong Liew, Wan Zurina Samad, Norazzizi Nordin, Poh Lee Loh, Joon Ching Juan, Mohd Ambar Yarmo, Badrul Hisham Yahaya, Rahimi M. Yusop
Chinese Journal of Catalysis 36 (2015)

Apoptosis in lung cancer cells induced by virgin cocnut oil
N‘A Kamalaldin, MR Yusop, SA Sulaiman, BH Yahaya
Regenerative Research 4(1) 2015 30-36

DEVELOPMENT OF A RAPID CONTINUOUS FLOW SALT LEACHING KIT FOR FABRICATION OF POLY(3-HYDROXYBUTYRIC ACID-CO-3-HYDROXYVALERATE) (PHBV) POROUS 3-D SCAFFOLD
Syazwan Aizad, Badrul Hisham Yahaya, Saiful Irwan Zubairi
(2015) Jurnal Teknologi 75 (1) pp. 193-199
DOI: http://dx.doi.org/10.11113/jt.v75.3903

GUIDELINES FOR NUCLEIC ACID DETECTION AND ANALYSIS IN HEMATOLOGICAL DISORDERS
ROSLINE HASSAN, AZLAN HUSIN, SARINA SULONG, SURINI YUSOFF, MUHAMMAD FARID JOHAN,BADRUL HISHAM YAHAYA, CY ANG,SELAMAH GHAZALI AND CHEONG SOON KENG
Malaysian J Pathol 2015; 37(2) : 165 – 173

Curcumin improves the efficacy of cisplatin by targeting cancer stem-like cells through p21 and Cyclin D1-mediated tumour cell inhibition in non-small cell lung cancer (NSCLC) cell lines
Puteri Baharuddin, Kamal Shaik Fakiruddin, Nazilah Satar, Norashikin Zakaria, Moon Nian Lim, Narazah Mohd Yusoff, Zubaidah Zakaria, Badrul Hisham Yahaya
Oncol Rep. 2016 Jan;35(1):13-25. doi: 10.3892/or.2015.4371.

2014

Multiplex amplification refractory mutation system (MARMS) for the detection of β-globin gene mutations among the transfusion-dependent β-thalassemia Malay patients in Kelantan, Northeast of Peninsular Malaysia.
Hanafi S, Hassan R, Bahar R, Abdullah WZ, Johan MF, Rashid ND, Azman NF, Nasir A, Hassan S, Ahmad R, Othman A, Ibrahim MI, Sukeri S, Sulong S, Yusoff S, Mohamad NS,
Hussein A, Hassan R, Yusoff N, Yahaya BH, Ismail E, Yussof NK, Salleh S, Zilfalil BA.
Am J Blood Res. 2014 Sep 5;4(1):33-40. eCollection 2014.


Int J Mol Sci. 2014 Aug 26;15(9):15044-60. doi: 10.3390/ijms150915044.
A comparative study of non-viral gene delivery techniques to human adipose-derived mesenchymal stem cell.
Halim N1, Fakiruddin KS, Ali SA, Yahaya BH.

Int J Mol Sci. 2014 May 19;15(5):8835-45. doi: 10.3390/ijms15058835.
Molecular characterization of α- and β-thalassaemia among Malay patients.
Yatim NF, Rahim MA, Menon K, Al-Hassan FM, Ahmad R, Manocha AB, Saleem M, Yahaya BH.

BMC Complement Altern Med. 2014 May 29;14(1):176. doi: 10.1186/1472-6882-14-176.
Inhalation of honey reduces airway inflammation and histopathological changes in a rabbit model of ovalbumin-induced chronic asthma.
Kamaruzaman NA, Sulaiman SA, Kaur G, Yahaya B.

Madu alternatif rawat asma: Saintis USM temui cara kurangkan penyakit kronik [Ruangan Rencana Berita Harian (NSTP): 4 Januari 2014]

Honey-based inhaler for asthma

2013

Kamaruzaman NA, Kardia E, Kamaldin N', Latahir AZ, Yahaya BH. The rabbit as a model for studying lung disease and stem cell therapy: Biomed Res Int. 2013;2013:691830. doi: 10.1155/2013/691830. Epub 2013 Apr 8
Yahaya B, McLachlan G, Collie DD. BrdU pulse-labelling in vivo to characterise cell proliferation during regeneration and repair following injury to the airway wall in sheep: ScientificWorldJournal. 2013;2013:871932. doi: 10.1155/2013/871932. Epub 2013 Feb 28
Kardia E, Yusoff NM, Zakaria Z, Yahaya B. Aerosol-Based Delivery of FibroblastCells for Treatment of LungDiseases: J Aerosol Med Pulm Drug Deliv. 2013 Feb 14. [Epub ahead of print]
Yahaya B, McLachlan G, McCorquodale C, Collie D (2013). Gene Expression Changes Associated with the Airway Wall Response to Injury: PLoS ONE 8(4): e58930. doi:10.1371/journal.pone.0058930
Kamaruzaman NA, Sulaiman SA, Gurjeet K and Yahaya BH. Aerosolized Honey as a Regenerative Agent in Animal Model of Asthma: The Open Conference Proceedings Journal; Volume 4, 2013 – Journal Proceeding
Kamalaldin NA, Sulaiman SA, Seeni A and Yahaya BH. Virgin Coconut oil (VCO) Inhibits Cell Growth Via Apoptosis on Lung Cancer Cell Lines: The Open Conference Proceedings Journal; Volume 4, 2013 – Journal Proceeding
Minyak Kelapa Dara Rencat Kanser: Dewan Bahasa & Pustaka (DBP), Nurulain 'Atikah Kamaldin & Badrul Hisham Yahaya, Dewan Kosmik (Majalah Sains & Teknologi) ISSN 0128-6579 Julai 2013
Semburan Madu Ubati Asma: Dewan Bahasa & Pustaka (DBP); Nurfatin Asyikhin Kamaruzzaman & Badrul Hisham Yahaya. Dewan Kosmik (Majalah Sains & Teknologi) ISSN 0128-6579 Ogos 2013
Kunyit Pembunuh Kanser Sel Tunjang: Dewan Bahasa & Pustaka (DBP); Nazilah Abdul Satar & Badrul Hisham Yahaya. Dewan Kosmik (Majalah Sains & Teknologi) ISSN 0128-6579 Ogos 2013

2012

Patar, A.A. and B.H. Yahaya, 2012. The Analysis of Aquoues and Ethanolic Extracts of Malaysian Mikania Cordata Leaves towards the Potential for Medicinal Substances. Eur. J. Sci. Res., 73: 434-440
Ahmad Z. Latahir., Badrul H. Yahaya. Blinded brushing technique as a novel method to inflict injury on rabbit tracheal airway epithelium structure: Journal of Animal and Veterinary Advances, 2012, 20, 3772-3775
Yahaya, B. Understanding cellular mechanisms underlying airway epithelial repair: Selecting the most appropriate animal models: ScientificWorldJournal. 2012;2012:961684. doi: 10.1100/2012/961684. Epub 2012 Sep 23
Ahmad, Z.L., Tuan Sharif, S.E., Zakaria, Z., Yahaya, B. ANALYSIS OF PATHOPHYSIOLOGICAL CHANGES IN REGENERATION AND REPAIR OF RABBIT AIRWAY TRACHEAL EPITHELIUM IN RESPONSE TO INDUCED-INJURY: Journal of Regenerative Research E-ISSN 2232-0822 Volume 1, Suppl 1, Tissue Engineering and Regenerative Medicine Society of Malaysia (TESMA), 2012 – Abstract
Badrul Yahaya, Caroline McCorquodale, Alison Baker, Peter Tennant, Gerry McLachlan, David Collie. GENE EXPRESSION PROFILING OF TIME-DEPENDENT CHANGES ASSOCIATED WITH REGENERATION AND REPAIR OF AIRWAY EPITHELIUM: Journal of Regenerative Research E-ISSN 2232-0822 Volume 1, Suppl 1 , Tissue Engineering and Regenerative Medicine Society of Malaysia (TESMA), 2012 – Abstract
Khalilah Haris, Samhani Ismail, Zamzuri Idris, Badrul Hisham Yahaya, Abdul Aziz Mohamed Yusoff , 2012, MICROARRAY GENE EXPRESSION PROFILING ANALYSIS FOR THE RESPONSE OF HUMAN GLIOMA U87 CELLS TO ALOE EMODIN TREATMENT: AKEPT 2nd Global Annual Young Researchers Conference & Exhibition 2012,  – Conference Proceeding
Kehebatan Sel Tunjang (Ruangan: Genetik Manusia), Dewan Bahasa & Pustaka (DBP), Badrul Hisham Yahaya, Dewan Kosmik (Majalah Sains & Teknologi) ISSN 0128-6579 Feb 2012, 2012
Sel Tunjang Penyembuh Penyakit? (Ruangan: Genetik Manusia), Dewan Bahasa & Pustaka (DBP), Badrul Hisham Yahaya, Dewan Kosmik (Majalah Sains & Teknologi) ISSN 0128-6579 Mac 2012 , 2012
Sel Tunjang Membaiki Tisu Yang Rosak (Ruangan: Genetik Manusia), Dewan Bahasa & Pustaka (DBP), Badrul Hisham Yahaya, Dewan Kosmik (Majalah Sains dan Teknologi) ISSN 0128-6579, 2012
Rintangan Terhadap Jangkitan HIV (Ruangan: Genetik Manusia), Dewan Bahasa & Pustaka (DBP), Badrul Hisham Yahaya, Dewan Kosmik (Majalah Sains & Teknologi) ISSN 0128-6579 Mei 2012, 2012
Sel Tunjang Mampu Merawat HIV? (Ruangan: Genetik Manusia), Dewan Bahasa & Pustaka (DBP), Badrul Hisham Yahaya, Dewan Kosmik Majalah Sains dan Teknologi) ISSN 0128-6579, 2012

2011

Badrul Hisham Yahaya, Gerry McLachlan, Christina Vrettou & David Collie. Optimising the quality and integrity of RNA samples from bronchial airway tissues: Asia Pacific J. Mol. Biol. Biotechnol, 2011, 19, 1, 19-27
Yahaya, B, A. Baker, P. Tennant, G. McLachlan, D.D.S. Collie (2011): -Expression of candidate gene-associated cell types during regeneration and repair of sheep airway epithelium following endobronchial brushing, 9th Malaysia Genetic Congress 28th - 30th Sept 2011 Pullman Hotel, Kuching Sarawak, Pullman Hotel Kuching Sarawak, 13 – Conference Proceeding
Yahaya B, Baker A, Tennant P, Smith SH, Shaw DJ, McLachlan G, Collie DD.
Analysis of airway epithelial regeneration and repair following endobronchial brush biopsy in sheep. Exp Lung Res. 2011 Nov;37(9):519-35. doi: 10.3109/01902148.2011.605513.

 

2009

Ivyna Bong Pau Ni, Zubaidah Zakaria, Badrul Hisham Yahaya, Ten Sew Keoh, Sharifah Noor Akmal Syed Hussain., Gene Expression Profiling of Malaysian Breast Carcinomas using cDNA-mediated Annealing, Selection, Extension and Ligation (DASL) Assay., Malaysian Journal of Biochemistry and Molecular Biology (2009) 17(2), 1-8, 2009, 17, 8
Yahaya, B., G. McLachlan, D.D.S. Collie. Optimising the quality of RNA from ovine lung tissues for microarray analysis. Abstract published in Human Gene Therapy. April 2009, 20(4): 396-422, Mary Ann Liebert, Inc., 2009
Yahaya, B.H., McLachlan,G. and Collie,D.S. Molecular study of gene expression during airway regeneration and repair following bronchial brushing in ovine generation of Ovis aries keratin 5 (KRT5) mRNA: mRNA sequences published in Genbank database (Accession: GQ372827.1): http://www.ncbi.nlm.nih.gov/nuccore/GQ372827.1, GeneBank Database, 2009
Yahaya,B.H., McLachlan,G. and Collie,D.S., Molecular study of gene expression during airway regeneration and repair following bronchial brushing in ovine generation of Ovis aries forkhead box J1 (HFH4) mRNA: mRNA sequences published in Genbank database (ACCESSION: GQ372829): http://www.ncbi.nlm.nih.gov/nuccore/255969804, GeneBank Database, 2009
Yahaya,B.H., McLachlan,G. and Collie,D.S., Molecular study of gene expression during airway regeneration and repair following bronchial brushing in ovine generation of Ovis aries beta-tubulin (TUBB) mRNA. mRNA sequences published in Genbank database (ACCESSION: GQ338157) http://www.ncbi.nlm.nih.gov/nuccore/GQ338157.1, GeneBank Database, 2009
Yahaya,B.H., McLachlan,G. and Collie,D.S., Molecular study of gene expression during airway regeneration and repair following bronchial brushing in ovine generation of Ovis aries beta catenin (CTNNB) mRNA. mRNA sequences published in Genbank database (ACCESSION: GQ372826) http://www.ncbi.nlm.nih.gov/nuccore/GQ372826.1, GeneBank Database, 2009

 

2008

Badrul Hisham Y, Rosline H, Abdul Aziz B, Narazah MY. The use of denaturing HPLC as a Rapid Screening Method for detection of polymorphisms in exon 26 of the multi-drug resistance (MDR1) gene in Malay Patients with Leukemia: Malaysian Journal of Biochemistry and Molecular Biology (2008) 16(1), 30-33, 2008, 16, 30-33
Yahaya BH, McLachlan G, Baker A, Tennant P, Smith S, and Collie DDS. Understanding the role of cell response in airway repairs after injury. Abstract published in Human Gene Therapy. April 2008, 19(4): 402-422, Mary Ann Liebert, Inc., 2008

 

2007

Badrul Hisham Y, Aliza MY, Zaiton Y, Puteri JN, Norsiah MD, Hishamshah I, Zubaidah Z. Chimerism analysis in patients with acute lymphoblastic leukaemia after allogeneic haematopoietic stem cell transplantation: Malaysian Journal of Biochemistry and Molecular Biology (2007) 15(2), 84-87, 2007, 15, , 84-87

 

2006

Y. Badrul Hisham, H. Rosline, W. M. Wan Maziah, S. Mohammad Ros, B. Abdul Aziz, B. Norsaadah, M. Y. Narazah. Screening for 3435C>T and G2677G>T/A Polymorphisms of Multi-drug Resistance (MDR1) Gene in Malay Patients with Leukemia: Malaysian Journal of Biochemistry and Molecular Biology (2006) 14, pg 18-24., 2006, 14, , 18-24

 

2005

Y. Badrul Hisham, H. Rosline, W. M. Wan Maziah, S. Mohammad Ros, B. Abdul Aziz, B. Norsaadah, M. Y. Narazah. Rapid Screening for C3435T Polymorphism in Exon 26 of the Multi-drug Resistance (MDR1) Abstract published in The Malaysian Journal of Medical Sciences, Vol. 12, Suppl. 1, 2005, pg 61