Infectious disease is also known as communicable diseases resulting from the infection transmitted by some pathogenic microorganisms such as viruses, bacteria, fungi, protozoa and multicellular parasites. Dynamic evolutionary of these microorganisms for the past few decades has a very significant importance in emerging and re-emerging infectious diseases nowadays. Even with the advances in the development of new vaccines, antivirals and many types of antimicroorganisms to combat the dissemination of many infectious diseases cause by various of these microorganisms have been successfully developed, some of them still pose a big threat and significant burden to the populations health and economic. Studies on microbial infections inevitably would involve dynamic cross-interrelation between diverse host range and pathogens. Basic understanding on various mechanisms involved in establishing a successful infection which eventually leads to exacerbation and dissemination of disease is pivotal to enable subsequent planning or effort in developing various ways to combat such diseases (cause by microbial pathogens).
Infectomic cluster (IC)focuses on the study of microbial infections using “omic” approaches ranging from genomics, proteomics and transcriptomics. Various aspects regarding the metabolisms, molecular interactions between infectomes encoded both in host and microbial pathohens genomes, and molecular pathogenesis of diseases are some of the main interests which moves the research activities in our cluster. There are three main research groups under the IC currently carrying research on three main microorganism themes – bacteria, fungi and virus. The ultimate goal of the cluster is to serve the community by transforming basic research findings into applied medicine for the betterment and sustainable health. Currently, the topics of our research are molecular mycology of candidiasis (fungi), molecular virology of norovirus (viral gastroenteritis), RNomic in identification and characterization of non-coding RNA in pathogens (bacteria), development of nucleic acid aptamer and biosensor, molecular diagnosis and vaccinology. We also expedite technology transfer in line with the vision of the institute to keep abreast with the latest research and technology. IC aims to promote collaborative interdisciplinary research by working together with national and international basic scientists, clinicians and private sectors, to bridge gaps in coordinating existing capabilities/strengths for combating infectious disease. As one of entities at AMDI, postgraduate academic programme is also one of the interests in our cluster. Therefore, we aim to implement a competitive postgraduate programme in near future to support the academic enhancement at AMDI.